It's definitely an adjustment, sacrificing one-handed accessibility for a larger screen. It's a little harder to take food pics lol, and I found myself having to use both hands when reading while lying in bed. But because of my bad vision in my right eye, I can definitely appreciate the larger screen for reading.

I have yet to really play with the camera but I've definitely noticed it's improved ability for taking photos in low-light conditions.

I'm really excited to test out the quick autofocus with my puppy; taking non-blurry pics of a hyper pup is one of the hardest thing to do.

My only real complaint is a temporary one -- most third-party apps haven't been redesigned to support the larger screen yet, so they all look like blown-up zoomed versions of the 5S. Surely this will become a non-issue soon.